Exendin-4 increases intracellular cAMP levels in colon cancer CT26 cells, activates the PKA pathway, and inhibits the activity of signaling kinases GSK3 and ERK1/2, consequently suppressing CT26 cell proliferation (152)
Clin Endocrinol 1983;19:365-76
the medication enhances, not replaces, these changes Genetics: Differences in receptor response mean some patients naturally respond better to one treatment than the other Starting weight: Higher BMI often leads to greater weight loss in kilograms, though percentage loss is similar Other medications: Certain drugs can reduce effectiveness by counteracting appetite suppression Difference Between Mounjaro and Wegovy: Side Effects Side effects are a key factor when choosing between Mounjaro and Wegovy, as tolerability affects adherence and outcomes Common side effects (both): Nausea Vomiting Diarrhoea Constipation Most noticeable during early dose escalation In the SURMOUNT-5 trial, Discontinuation due to side effects was lower with tirzepatide (2.7%) Individual response varies: Some patients tolerate Wegovy better Others find Mounjaro easier to manage No reliable way to predict tolerance in advance Important practical difference: Mounjaro may reduce the absorption of oral medications during dose increases This includes the combined oral contraceptive pill Additional contraceptive precautions are recommended for 4 weeks after each dose escalation Mounjaro vs Wegovy UK: Which Should You Choose
Shankar V, Wilhelmy J, Curtis EJ, Michael B, Cervantes L, Mallajosyula V, et al
Im gonna make it what they want
